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Stressing Out about Cancer Immunotherapy
Xue-Yan He1, David Ng1, Linda Van Aelst1
1Cold Spring Harbor Laboratory, Cancer Center, Cold Spring Harbor, NY 11724, USA.
Abstract:
Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells-the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3-as a potent, immunosuppressive effect of stress on cancer.
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