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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
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Peptic Ulcer Disease I: Introduction01:30

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Functional Dyspepsia in the Elderly.

Marjorie M Walker1,2, Nicholas J Talley3,4

  • 1Faculty of Health & Medicine, University of Newcastle, Callaghan, 2305, NSW, Australia.

Current Gastroenterology Reports
|November 14, 2019
PubMed
Summary
This summary is machine-generated.

Functional dyspepsia in the elderly requires careful diagnosis to exclude organic causes. While prevalence decreases with age, investigations and management strategies are crucial for effective treatment.

Keywords:
AgingDuodenumDyspepsiaEosinophilMicrobiomePathologyStomach

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Area of Science:

  • Gastroenterology
  • Geriatric Medicine
  • Internal Medicine

Background:

  • Functional dyspepsia (FD) is a prevalent gastrointestinal disorder defined by Rome IV criteria.
  • This review focuses on FD specifically within the elderly population, addressing its unique epidemiological, investigative, and therapeutic aspects.

Purpose of the Study:

  • To review the epidemiology, investigation, and treatment of functional dyspepsia in elderly patients.
  • To highlight recent findings and ongoing research into the pathophysiology and management of FD in this demographic.

Main Methods:

  • Literature review of recent studies on functional dyspepsia in the elderly.
  • Analysis of diagnostic criteria, including mandatory upper gastrointestinal endoscopy.
  • Evaluation of current and emerging treatment strategies.

Main Results:

  • Dyspepsia prevalence declines in the elderly, but organic diseases must be excluded.
  • Potential pathophysiological factors include duodenal immune disturbances and microbial disruption.
  • First-line treatments include proton pump inhibitors and tricyclic antidepressants; herbal remedies show limited efficacy.

Conclusions:

  • Accurate diagnosis is paramount in managing functional dyspepsia in the elderly.
  • Further research is needed to fully understand FD prevalence and pathophysiology in older adults.
  • Excluding organic disease remains a critical component of dyspepsia management in this age group.