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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
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Self-assembled injectable biomolecular hydrogels towards phototherapy
Ruirui Xing1, Yamei Liu, Qianli Zou
1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. yanxh@ipe.ac.cn.
Nanoscale
|November 16, 2019
Summary
This review explores injectable biomolecular hydrogels for phototherapies like photodynamic therapy (PDT) and photothermal therapy (PTT). These advanced hydrogels offer biocompatibility and tunable properties for biomedical applications.
Area of Science:
- Biomaterials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Biomolecular hydrogels offer biocompatibility, tunable properties, and degradability for biomedical uses.
- Injectable hydrogels are crucial for minimally invasive therapeutic delivery.
- Phototherapies like PDT and PTT show promise but require effective delivery systems.
Purpose of the Study:
- To review recent advancements in supramolecular injectable biomolecular hydrogels.
- To highlight their applications in antitumor and antibacterial phototherapies.
- To discuss challenges and future directions in photo-functional hydrogel development.
Main Methods:
- Literature review of supramolecular biomolecular hydrogels.
- Analysis of hydrogel properties: injectability, mechanical characteristics, and degradation.
- Evaluation of phototherapeutic efficacy in preclinical models.
Main Results:
- Biomolecular hydrogels demonstrate significant potential in combined photodynamic and photothermal therapy (PDT/PTT).
- Injectable hydrogels facilitate targeted drug delivery and localized treatment.
- Tailored hydrogel design enhances therapeutic outcomes and minimizes side effects.
Conclusions:
- Injectable biomolecular hydrogels are promising platforms for advanced phototherapies.
- Further research into hydrogel design and clinical translation is warranted.
- These materials offer a versatile approach for combating cancer and bacterial infections.
