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Related Concept Videos

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Jan 3, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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Emerging Anticancer Potentials of Selenium on Osteosarcoma.

Kok-Lun Pang1, Kok-Yong Chin1

  • 1Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.

International Journal of Molecular Sciences
|November 17, 2019
PubMed
Summary
This summary is machine-generated.

Selenium compounds show anticancer effects against osteosarcoma cells in lab studies, reducing tumor size in animals. However, human evidence for selenium

Keywords:
bonecancerchemopreventionosteoblastsoxidative stresstrace elements

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Area of Science:

  • Biochemistry
  • Oncology
  • Trace Element Research

Background:

  • Selenium is an essential trace element with known physiological functions.
  • In vitro studies suggest selenium exhibits anticancer properties, potentially effective against osteosarcoma.

Purpose of the Study:

  • To review existing evidence on the anticancer activity of both inorganic and organic selenium compounds specifically against osteosarcoma.
  • To consolidate findings from cellular and animal studies regarding selenium's impact on osteosarcoma.

Main Methods:

  • Literature review of in vitro cellular studies on osteosarcoma cell lines.
  • Analysis of in vivo animal studies involving osteosarcoma xenografts.
  • Examination of the limited human studies investigating selenium and osteosarcoma.

Main Results:

  • Inorganic and organic selenium demonstrated cytotoxicity, anti-proliferative, and pro-apoptotic effects on osteosarcoma cell lines.
  • Potential mechanisms include induced oxidative stress, p53 activation, and caspase cascade.
  • Animal studies showed reduced tumor size, but not complete elimination; human data remains inconclusive.

Conclusions:

  • Selenium compounds exhibit promising anticancer properties against osteosarcoma in experimental settings.
  • Further human clinical trials are necessary to establish the efficacy and safety of selenium for osteosarcoma treatment.
  • Challenges remain in controlling selenium dosage and release for targeted cancer therapy.