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Updated: Jan 3, 2026
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Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
Published on: September 27, 2019
12.9K
Itch in Chronic Wounds: Pathophysiology, Impact, and Management
Michela Iannone1, Agata Janowska1, Valentina Dini1
1Department of Dermatology, University of Pisa, 56126 Pisa, Italy.
Medicines (Basel, Switzerland)
|November 17, 2019
Summary
Itch in chronic wounds significantly impacts quality of life and healing. Current management strategies are insufficient, highlighting the need for further research into the pathophysiology of wound itch.
Area of Science:
- Dermatology
- Wound Care
- Pathophysiology
Background:
- Chronic wounds often present with pruritus (itch), affecting patient well-being.
- Understanding the mechanisms of itch in chronic wounds is crucial for effective management.
Purpose of the Study:
- Analyze itch characteristics and pathophysiology in chronic wounds.
- Assess the impact of itch on quality of life and wound healing.
- Identify optimal prevention and treatment strategies for wound-related itch.
Main Methods:
- Systematic literature review of multiple databases (MEDLINE, PubMed, Embase, Scopus, ScienceDirect, Cochrane Library).
- Inclusion of 11 English-language articles focusing on itch pathophysiology and management in chronic wounds.
Main Results:
- Itch in chronic wounds is associated with xerosis, wound size, necrotic tissue, exudate, edema, sclerosis, granulation tissue, dermatitis, and bacterial burden.
- Chronic wound itch negatively correlates with patient quality of life.
Conclusions:
- Current non-specific treatments for chronic wound itch lack validation.
- Further research is essential to elucidate itch pathophysiology, evaluate topical treatments, characterize itch sensations, identify biomarkers, and develop evidence-based guidelines.
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