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Related Concept Videos

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Natriuretic Peptides (BNP)
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Mitral Regurgitation I: Introduction01:20

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
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Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

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Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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Heart Failure III: Clinical Manifestations01:26

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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Biomarkers and Right Ventricular Dysfunction.

Natasha M Pradhan1, Christopher Mullin2, Hooman D Poor1

  • 1Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai Hospital, 1 Gustave L. Levy Place, New York, NY 10029-5674, USA.

Critical Care Clinics
|November 18, 2019
PubMed
Summary
This summary is machine-generated.

Right ventricular failure is a critical condition often caused by pulmonary embolism or hypertension. Laboratory biomarkers aid in diagnosing and managing this dysfunction in critically ill patients.

Keywords:
BiomarkersBrain natriuretic peptidePulmonary embolismPulmonary hypertensionRight ventricular dysfunctionTroponin

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Area of Science:

  • Critical care medicine
  • Cardiology
  • Pulmonology

Background:

  • Right ventricular failure is prevalent in critically ill patients.
  • It often stems from pulmonary embolism, pulmonary hypertension, sepsis, or acute respiratory distress syndrome.
  • Right ventricular dysfunction is linked to adverse outcomes and poses management challenges.

Purpose of the Study:

  • To discuss the pathophysiology of right ventricular failure.
  • To review the application of laboratory biomarkers in managing right ventricular dysfunction in critical care.

Main Methods:

  • Literature review of right ventricular failure pathophysiology.
  • Review of commonly used laboratory biomarkers for right ventricular dysfunction.
  • Focus on applications in the critical care setting.

Main Results:

  • Right ventricular failure has diverse causes and significant implications in critical illness.
  • Laboratory biomarkers offer a rapid, noninvasive, and accurate method for diagnosis and management.
  • Biomarker utility is crucial for optimizing care in critically ill patients with right ventricular dysfunction.

Conclusions:

  • Understanding right ventricular failure pathophysiology is key.
  • Laboratory biomarkers are invaluable tools for timely diagnosis and effective management of right ventricular dysfunction.
  • Strategic use of biomarkers can improve outcomes for critically ill patients.