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Biomarker Panels in Critical Care.
Susan R Conway1, Hector R Wong2
1Division of Critical Care Medicine, Children's National Medical Center, 111 Michigan Avenue Northwest, Washington, DC 20010, USA; Department of Pediatrics, George Washington University School of Medicine, Washington, DC, USA.
Biomarker panels can improve critical care by identifying patient prognosis and disease mechanisms. This review covers their development and application in sepsis, acute respiratory distress syndrome, and acute kidney injury.
Area of Science:
- Biomarker discovery and validation in critical care medicine.
Background:
- Biomarker panels offer potential for patient stratification in critical care.
- Understanding prognosis and pathophysiology is key in managing critical illnesses.
Purpose of the Study:
- To discuss the discovery, validation, and clinical translation of biomarker panels.
- To review the literature on biomarker panel applications in specific critical care conditions.
Main Methods:
- Literature review of biomarker panels in critical care.
- Focus on sepsis, acute respiratory distress syndrome (ARDS), and acute kidney injury (AKI).
Main Results:
- Biomarker panels are crucial for advancing critical care medicine.
- Successful translation requires robust discovery and validation processes.
- Current literature highlights their utility in sepsis, ARDS, and AKI.
Conclusions:
- Biomarker panels are essential tools for personalized critical care.
- Further research and clinical validation are needed for widespread adoption.
- These panels aid in prognosis and understanding disease in critical conditions.
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