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Percutaneous Interstitial Nd:YAG Laser Therapy for Axillary Osmidrosis
Yu-Jia Geng1, Tian Li1, Lei Wen1
1Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
Lasers in Surgery and Medicine
|November 19, 2019
Summary
Nd:YAG laser treatment reduced apocrine gland size and expression of odor-related molecules like apolipoprotein D and androgen receptor, suggesting a potential therapy for osmidrosis.
Area of Science:
- Dermatology
- Laser Medicine
- Biochemistry
Background:
- Investigating the impact of percutaneous interstitial Nd:YAG laser irradiation on apocrine glands.
- Focusing on molecules linked to odor production: apolipoprotein D (ApoD) and androgen receptor (AR).
Observation:
- Nd:YAG laser irradiation (pulsed or continuous) was applied to pigskin.
- Histology, western blot, and qRT-PCR analyses were performed at 1 hour, 1 week, and 1 month post-treatment.
Findings:
- Irradiation led to apocrine gland rounding and enlarged cavities by 1 month.
- Significant decrease in ApoD and AR protein and expression levels observed 1 month after continuous 10W irradiation.
- Variations in ApoD and AR levels were noted across different treatment groups.
Implications:
- Percutaneous interstitial Nd:YAG laser irradiation shows promise as a safe and effective treatment for axillary osmidrosis.
- The treatment may reduce the production of odor-causing compounds like unsaturated fatty acids and steroids.
