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Updated: Jan 3, 2026
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
Effect of Endomorphin-1 on Contractile Activity of Rat Mesenteric Lymphatic Vessels
1Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency of Russia, Kuzmolovsky, Leningrad Region, Russia. olga2278@mail.ru.
Abstract:
We studied the effect of endomorphin-1 on isolated mesenteric lymphatic vessels in rats. It was found that endomorphin-1 caused a dose-dependent increase in the contractile activity of lymphangions, which was associated with stimulation of intracellular calcium depots. The observed effect of endomorphin-1 in isolated lymphatic vessels has a complex mechanism; it depends on the concentration of the applied peptide and is probably determined by its interaction with non-opioid receptors.
