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Synthesis and iron coordination properties of schizokinen and its imide derivative
Hataichanok Chuljerm1, Yu-Lin Chen, Somdet Srichairatanakool
1Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK. agostino.cilibrizzi@kcl.ac.uk.
Abstract:
The iron(iii) affinity constants for schizokinen and its imide derivative are reported for the first time. Surprisingly, schizokinen possesses a higher affinity for iron(iii) than desferrioxamine B; log KFeIII (FeL), 36.2 and 30.6, respectively. This increase in value is associated with the substitution of one hydroxamate function by an α-hydroxycarboxylate grouping. By virtue of the similarity of siderophore-iron(iii) complexes and siderophore-gallium(iii) complexes, schizokinen (which is a Gram positive siderophore) has potential for 68Ga PET-based imaging.
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