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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
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Spirocyclic Motifs in Natural Products
Evgeny Chupakhin1, Olga Babich1,2, Alexander Prosekov2
1Immanuel Kant Baltic Federal University, 236016 Kaliningrad, Alexandra Nevskogo 14, Russia.
Molecules (Basel, Switzerland)
|November 21, 2019
Summary
Spirocyclic structures are vital in natural products and drug discovery. This review analyzes the structural diversity and prevalence of spirocyclic motifs in natural compounds, filling a gap in scientific literature.
Area of Science:
- Medicinal Chemistry
- Natural Product Chemistry
- Organic Chemistry
Background:
- Spirocyclic motifs are increasingly recognized as privileged structures in drug discovery.
- These unique cyclic structures are frequently found in natural products.
- A comprehensive analysis of spirocyclic diversity in natural products has been lacking.
Purpose of the Study:
- To analyze the structural diversity of spirocyclic moieties in natural products.
- To assess the relative abundance of different spirocyclic motifs.
- To catalog unique spirocyclic compounds reported in scientific literature.
Main Methods:
- Literature review of natural products containing spirocyclic systems.
- Structural analysis and classification of identified spirocyclic motifs.
- Database compilation of unique spirocyclic natural compounds.
Main Results:
- Identification and categorization of diverse spirocyclic scaffolds.
- Quantification of the prevalence of various spirocyclic systems.
- Highlighting underrepresented and abundant spirocyclic structures in nature.
Conclusions:
- Spirocyclic natural products exhibit significant structural diversity.
- Understanding this diversity can guide future drug discovery efforts.
- This review provides a foundational analysis for exploring spirocyclic natural product chemistry.
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