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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

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Published on: November 9, 2019

Recent advances in cobalt-catalysed C-H functionalizations.

Alessio Baccalini¹, Stefania Vergura¹, Pravas Dolui²

¹Department of Chemistry, University of Pavia, Viale Taramelli 10, Pavia 27100, Italy. gz@unipv.it.

Organic & Biomolecular Chemistry

|November 21, 2019

Summary

Cobalt catalysis is emerging as a cost-effective alternative to noble metals for C-H functionalization. This review highlights recent advances in cobalt-catalyzed C(sp2)-H and C(sp3)-H bond transformations, including enantioselective methods.

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Published on: June 20, 2014

Area of Science:

Organic Chemistry
Catalysis
Sustainable Chemistry

Background:

Noble metal catalysts (Pd, Rh, Ir) traditionally dominate C-H functionalization.
Cobalt (Co) offers a more sustainable alternative due to its low cost, availability, and low toxicity.
Recent years have seen a surge in Co-catalyzed C-H functionalization research.

Purpose of the Study:

To review recent advancements in cobalt-catalyzed C-H functionalization reactions.
To cover both C(sp2)-H and C(sp3)-H bond functionalizations.
To provide a comprehensive overview of enantioselective Co-catalyzed transformations.

Main Methods:

Literature review of recent developments in Co-catalyzed C-H functionalization.
Focus on C(sp2)-H and C(sp3)-H bond activation strategies.
Analysis of enantioselective methodologies in Co catalysis.

Main Results:

Exponential growth in Co-catalyzed C-H functionalization examples over recent decades.
Significant progress in applying Co catalysts to both sp2 and sp3 C-H bonds.
Development of enantioselective Co-catalyzed reactions.

Conclusions:

Cobalt catalysis is a rapidly advancing and sustainable field for C-H functionalization.
Co catalysts are increasingly replacing noble metals in various organic transformations.
Enantioselective Co-catalyzed reactions are a key area of ongoing research and development.