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Cellular Attachment and Entry Factors for Chikungunya Virus.
1Department of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Viruses
|November 23, 2019
Summary
Chikungunya virus (CHIKV) infects many cell types, suggesting a common cellular receptor. This review details known CHIKV cellular receptors and attachment factors for virus entry.
Area of Science:
- Virology
- Cell Biology
- Infectious Diseases
Background:
- Chikungunya virus (CHIKV) is a significant alphavirus with broad host tropism.
- Its ability to infect diverse cells, tissues, and species implies the use of a common cellular entry mechanism.
- Understanding CHIKV's cellular interactions is crucial for developing antiviral strategies.
Purpose of the Study:
- To review and consolidate current knowledge on cellular receptors utilized by CHIKV.
- To identify and discuss attachment factors involved in CHIKV cell entry.
- To provide a comprehensive overview of CHIKV-host cell interactions.
Main Methods:
- Literature review of published research on CHIKV.
- Analysis of studies investigating CHIKV cellular tropism.
- Synthesis of data on identified CHIKV receptors and attachment factors.
Main Results:
- CHIKV demonstrates broad cellular and host tropism.
- Evidence suggests CHIKV utilizes ubiquitously expressed cellular receptors for entry.
- Key attachment factors and cellular receptors mediating CHIKV infection are discussed.
Conclusions:
- The ubiquitous nature of CHIKV infection is linked to common cellular receptors.
- Identifying these receptors and attachment factors is vital for understanding CHIKV pathogenesis.
- This knowledge is fundamental for future therapeutic interventions against CHIKV.
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