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Published on: May 17, 2019
Phototherapy for Cutaneous T-Cell Lymphoma
1Geisel School of Medicine at Dartmouth College, Box 163, Kellogg Building, 45 Dewey Field Road, Hanover, NH 03755, USA.
Abstract:
Phototherapy with psoralen and ultraviolet A (PUVA) or narrowband-UVB (NBUVB) is frequently used for the patch and plaque stages of mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma. This article provides practical guidelines for the design and implementation of a phototherapy protocol for early stage MF, including an overview of treatment phases, response criteria, and considerations in the selection of a light source. Several evolving topics in phototherapy research are also discussed, including the relative efficacy of PUVA versus NBUVB, the role of maintenance therapy, risk of photocarcinogenicity, and combination therapies.

