Primary Cutaneous CD30-Positive Lymphoproliferative Disorder With Gamma-Delta T-Cells: A Molecular-Annotated Case...

We report a case of a patient with a CD30-positive lymphoproliferative disorder (CD30+LPD) comprised of gamma-delta T-cells. After 4 years of clinical follow-up with conservative management and multiple biopsies, the indolent course and histopathologic findings best support a diagnosis of primary cutaneous anaplastic large cell lymphoma (pcALCL) with concomitant lymphomatoid papulosis (LyP)-type lesions. Sequencing revealed missense mutations involving ADGRA2, EPHA7, ERBB2, LRP1B, NOD1, RAF1, RICTOR, and WDR90. No fusions were identified. Review of the copy-number profile revealed aneuploidy, which included gain of 1q, loss of 16q, and loss of 19p13.3. Altogether, these findings were insufficient to establish a diagnosis of pcGDTCL. We review the clinical, histopathologic, and molecular sequencing data pertaining to our rare patient as well as the recent literature on indolent CD30+LPD with gamma-delta T-cells.