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Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes
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Thyroid Hormone Transporters.

Stefan Groeneweg1, Ferdy S van Geest1, Robin P Peeters1

  • 1Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, the Netherlands.

Endocrine Reviews
|November 23, 2019
PubMed
Summary
This summary is machine-generated.

Thyroid hormone transporters like MCT8 and OATP1C1 are crucial for hormone availability. Mutations in these transporters cause disorders, with therapies like hormone analogues showing promise for MCT8 deficiency.

Keywords:
AHDSAllan-Herndon-Dudley syndromeMCT8MCT8 deficiencyOATP1C1thyroid hormonethyroid hormone transportthyroid hormone transporters

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Biology

Background:

  • Plasma membrane transporters regulate intracellular thyroid hormone levels.
  • Key transporters include monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4.
  • These transporters exhibit high specificity for thyroid hormones.

Purpose of the Study:

  • To review the current understanding of thyroid hormone transporters.
  • To explore the molecular basis and clinical implications of thyroid hormone transporter function.
  • To discuss animal models and therapeutic strategies for transporter deficiencies.

Main Methods:

  • Structure-function studies utilizing homology modeling.
  • Mutational screening to identify key transport residues.
  • Analysis of animal models to elucidate transporter roles.
  • Review of clinical data and therapeutic interventions.

Main Results:

  • Mutations in MCT8 and OATP1C1 are linked to significant clinical disorders.
  • Animal models, especially for MCT8, have provided crucial functional insights.
  • Thyroid hormone analogue therapy is an established treatment for MCT8 deficiency.

Conclusions:

  • Thyroid hormone transporters are vital for hormone bioavailability and function.
  • Understanding these transporters is key to addressing related genetic disorders.
  • Future research will likely uncover novel transporters and refine therapeutic approaches.