Related Experiment Video
Updated: Jan 3, 2026
06:24
Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis
Published on: October 7, 2021
3.8K
Rejuvenating subventricular zone neurogenesis in the aging brain
Ronald R Cutler1, Erzsebet Kokovay2
1Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States.
Current Opinion in Pharmacology
|November 23, 2019
Summary
Aging reduces neural stem cell function and neurogenesis, impacting cognition and repair. Rejuvenation strategies aim to restore youthful brain function by targeting these age-related declines.
Area of Science:
- Neuroscience
- Stem Cell Biology
- Aging Research
Background:
- Neural stem cells (NSCs) in the brain generate new neurons and glia throughout life.
- Neurogenesis is crucial for cognitive functions and brain repair mechanisms.
- Aging impairs NSC number and function, leading to reduced neurogenesis and cognitive decline.
Purpose of the Study:
- To review the aging process within the subventricular zone neurogenic niche.
- To explore various rejuvenation strategies for restoring youthful neurogenesis.
- To propose future research directions for translational outcomes.
Main Methods:
- Literature review of aging effects on the neurogenic niche.
- Analysis of diverse rejuvenation strategies (dietary, pharmacological).
- Identification of research gaps and future study proposals.
Main Results:
- Aging significantly diminishes neurogenesis by affecting the subventricular zone niche.
- Multiple rejuvenation interventions show potential in restoring neurogenesis.
- Current strategies offer promising avenues for combating age-related cognitive decline.
Conclusions:
- Rejuvenation strategies hold promise for restoring age-impaired neurogenesis.
- Further research is needed to translate these findings into clinical applications.
- Targeting the neurogenic niche is key to enhancing brain repair and cognition in aging individuals.
