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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Precision Medicine in Colorectal Surgery.

Sangeetha Prabhakaran1, Joseph Leong2, Nicholas J Petrelli3

  • 1Division of Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM, USA.

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|November 24, 2019
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Summary

Precision medicine advances in colorectal carcinoma improve patient selection for targeted therapies. Mutational analysis at diagnosis is crucial for guiding treatment and optimizing outcomes.

Keywords:
Colorectal surgeryPrecision medicinePredictive biomarkers

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Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Colorectal carcinoma (CRC) management has been significantly impacted by advancements in precision medicine.
  • Molecular profiling is increasingly central to tailoring treatment strategies.

Purpose of the Study:

  • To review recent progress in precision medicine for CRC.
  • To highlight the influence of these advances on screening, treatment, and prevention.
  • To emphasize the importance of molecular analysis in CRC patient care.

Main Methods:

  • Literature review of precision medicine in colorectal cancer.
  • Analysis of molecular techniques and their clinical applications.
  • Synthesis of current evidence on targeted therapies and resistance mechanisms.

Main Results:

  • Molecular techniques enable improved patient stratification for CRC therapies.
  • Mutational analysis at diagnosis is recommended to guide treatment decisions.
  • Emerging therapies show promise for specific patient subgroups.

Conclusions:

  • Precision medicine, guided by molecular analysis, is transforming CRC care.
  • Further research is needed to validate subgroup treatments and overcome resistance.
  • Optimizing CRC therapies can enhance efficacy and reduce toxicity.