Related Experiment Video

Updated: Jan 3, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

606

Precision Medicine in Colorectal Surgery

Sangeetha Prabhakaran1, Joseph Leong2, Nicholas J Petrelli3

  • 1Division of Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM, USA.

Surgical Oncology Clinics of North America
|November 24, 2019
PubMed

Insights

Precision medicine advances in colorectal carcinoma improve patient selection for targeted therapies. Mutational analysis at diagnosis is crucial for guiding treatment and optimizing outcomes.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Colorectal carcinoma (CRC) management has been significantly impacted by advancements in precision medicine.
  • Molecular profiling is increasingly central to tailoring treatment strategies.

Purpose of the Study:

  • To review recent progress in precision medicine for CRC.
  • To highlight the influence of these advances on screening, treatment, and prevention.
  • To emphasize the importance of molecular analysis in CRC patient care.

Main Methods:

  • Literature review of precision medicine in colorectal cancer.
  • Analysis of molecular techniques and their clinical applications.
  • Synthesis of current evidence on targeted therapies and resistance mechanisms.

Main Results:

  • Molecular techniques enable improved patient stratification for CRC therapies.
  • Mutational analysis at diagnosis is recommended to guide treatment decisions.
  • Emerging therapies show promise for specific patient subgroups.

Conclusions:

  • Precision medicine, guided by molecular analysis, is transforming CRC care.
  • Further research is needed to validate subgroup treatments and overcome resistance.
  • Optimizing CRC therapies can enhance efficacy and reduce toxicity.
Keywords:
Colorectal surgeryPrecision medicinePredictive biomarkers

More Related Videos

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

1.3K
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

9.9K

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
411