Related Experiment Video

Updated: Jan 3, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

6.8K

Precision Medicine and Targeted Therapies in Breast Cancer

Ian Greenwalt1, Norah Zaza2, Shibandri Das1

  • 1University Hospitals Cleveland Medical Center, MetroHealth Hospitals, Louis Stokes Veterans Administration Hospital, Case Western Reserve University, Cleveland, OH, USA.

Surgical Oncology Clinics of North America
|November 24, 2019
PubMed

Insights

Precision medicine and targeted therapies are revolutionizing breast cancer treatment, offering increasingly individualized care. Future advancements promise even more specialized approaches for this disease.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Breast cancer treatment has evolved significantly with the integration of precision medicine.
  • Targeted therapies, including endocrine and HER2-targeted agents, have improved patient outcomes.
  • Multigene assays, radiomics, and genetic subtyping represent advancements in personalized patient selection.

Purpose of the Study:

  • To describe the historical foundation of targeted therapy and precision medicine in breast cancer.
  • To explore the future directions and potential of these approaches in breast cancer management.
  • To highlight the shift towards individualized patient care in oncology.

Main Methods:

  • Review of historical data and landmark studies in targeted breast cancer therapy.
  • Analysis of current precision medicine tools, such as multigene assays and genetic subtyping.
  • Exploration of emerging technologies like radiomics for treatment personalization.

Main Results:

  • Targeted therapies have demonstrated efficacy in specific breast cancer subtypes.
  • Precision medicine enables more accurate patient selection for tailored treatments.
  • Advancements continue to refine the individualized management of breast cancer.

Conclusions:

  • Precision medicine and targeted therapies are fundamental to modern breast cancer care.
  • Continued research and technological innovation will further enhance personalized treatment strategies.
  • The future of breast cancer management lies in highly individualized and targeted approaches.
Keywords:
Breast cancerEndocrine therapyGenomicsHER2Multigene arrayPrecision medicineRadiomicsTargeted therapy

More Related Videos

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.2K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.3K