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Frozen-Section Tissue Processing in Mohs Surgery
1Oxford Dermatology, Mount Hawthorn, Perth, Western Australia.
Summary
Mohs micrographic surgery (MMS) optimizes tissue preservation for skin cancer. This review details frozen-section processing techniques, offering practical tips to enhance accuracy and avoid margin errors in MMS procedures.
Area of Science:
- Dermatology
- Surgical Pathology
- Oncology
Background:
- Mohs micrographic surgery (MMS) is a leading tissue-sparing method for skin cancer.
- Variability exists in MMS mapping and tissue processing techniques among practitioners.
Purpose of the Study:
- To review frozen-section tissue processing techniques specific to MMS.
- To discuss variations in processing and provide optimization strategies.
Main Methods:
- A literature search was conducted on PubMed focusing on MMS tissue processing.
- Publications detailing tissue processing methods in MMS were analyzed.
Main Results:
- Variations in debulking, embedding, and processing specific tissues (adipose, cartilage) were identified.
- Techniques to prevent false-positive/negative margins and advances in immunohistochemistry are discussed.
Conclusions:
- This article offers a practical guide to MMS tissue processing stages.
- It provides techniques and pearls to improve accuracy and optimize practice for better patient outcomes.
