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In Vitro Assay to Study Tumor-macrophage Interaction
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Published on: August 1, 2019

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The emerging role of long non-coding RNAs in tumor-associated macrophages

Dafei Han1, Yilong Fang1, Yawei Guo1

  • 1Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, China.

Journal of Cancer
|November 29, 2019
PubMed

Insights

Long non-coding RNAs (lncRNAs) influence tumor-associated macrophages (TAMs) functions, impacting tumor immunity. Understanding lncRNAs in TAMs offers potential for novel cancer diagnosis and treatment strategies.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Tumor-associated macrophages (TAMs) are key players in the tumor microenvironment (TME).
  • TAMs significantly influence tumor immunity and progression.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cellular functions.

Purpose of the Study:

  • To review the multifaceted roles of lncRNAs in regulating TAMs.
  • To explore lncRNA involvement in TAM polarization, epigenetic modulation, and signaling pathways.
  • To highlight lncRNAs as potential therapeutic and diagnostic targets in cancer.

Main Methods:

  • Literature review of recent studies on lncRNAs and TAMs.
  • Synthesis of findings on lncRNA functions in TAM biology.
  • Analysis of lncRNA-mediated mechanisms in the TME.

Main Results:

  • lncRNAs exhibit diverse functions in controlling TAM polarization towards pro-tumor or anti-tumor phenotypes.
  • lncRNAs modulate TAMs through epigenetic mechanisms, affecting gene expression.
  • lncRNAs participate in key signaling pathways that govern TAM behavior and function.

Conclusions:

  • lncRNAs are critical regulators of TAMs, influencing their role in tumor immunity.
  • Targeting lncRNAs offers a promising avenue for modulating TAMs in cancer therapy.
  • Further research into lncRNA-TAM interactions can lead to improved cancer diagnosis and treatment.
Keywords:
NF-κB pathwayTAMsepigeneticslncRNAspolarization

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