Related Experiment Video

Updated: Jul 16, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.6K

Tranexamic acid-induced fixed drug eruption confirmed by the drug lymphocyte transformation test

Kenji Kawaguchi1, Shotaro Kinoshita1, Motonao Ishikawa2

  • 1Postgraduate Clinical Training Center Tokyo Women's medical University Medical Center East Tokyo Japan.

Clinical Case Reports
|December 3, 2019
PubMed

Insights

Multiple fixed drug eruptions caused by tranexamic acid were identified using the lymphocyte transformation test (LTT). Diagnosis was complicated by concurrent drug-induced aseptic meningitis from loxoprofen.

Area of Science:

  • Pharmacology
  • Dermatology
  • Immunology

Background:

  • Fixed drug eruption (FDE) is a specific type of adverse drug reaction.
  • Tranexamic acid is increasingly used for various medical conditions.
  • Drug-induced aseptic meningitis is a known neurological side effect of some medications.

Observation:

  • A patient presented with recurrent, well-demarcated skin lesions consistent with FDE.
  • The patient was also experiencing symptoms suggestive of aseptic meningitis.
  • Loxoprofen was identified as a potential cause of aseptic meningitis.

Findings:

  • The lymphocyte transformation test (LTT) confirmed tranexamic acid as the causative agent for the multiple fixed drug eruptions.
  • This represents the first reported case of FDE specifically linked to tranexamic acid.
  • The simultaneous occurrence of FDE and drug-induced aseptic meningitis presented a diagnostic challenge.

Implications:

  • Highlights the potential for tranexamic acid to cause FDE, necessitating increased clinical awareness.
  • Emphasizes the importance of considering multiple concurrent adverse drug reactions in complex cases.
  • Suggests the utility of LTT in diagnosing FDE when drug causality is uncertain.
Keywords:
drug lymphocyte transformation testdrug‐induced aseptic meningitisfixed drug eruptionloxoprofentranexamic acid

More Related Videos

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

17.4K
Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs08:13

Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs

Published on: December 27, 2016

19.3K

Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...