PECULIARITIES OF CYTOKINE RESPONSE IN CHILDREN WITH SHIGELLOSIS AND CONCOMITANT CYTOMEGALOVIRUS INFECTION

The article presents the results of a comparative analysis of the level of interleukins of children with Shigellosis in different periods of the disease depending on the presents of CMV-infection in patients. To achieve the goal, 63 children aged from three to eight years old with Shigellosis were examined, who were treated at the Regional Children's Infectious Clinical Hospital of Kharkiv, Ukraine. It has been established that the presence of CMV in patients with Shigellosis leads to the development of cytokine imbalance which persists until the period of early convalescence. In the acute period of Shigellosis in children with CMV infection, the level of IL-1β significantly increases with unreliable fluctuations in the indices of TNF-α and IL-4. In children with Shigellosis without comorbidities, an increase in the level of all cytokines is recorded. In children with monoinfection to the period of convalescence, a significant dynamics of decrease in the levels of all interleukins was observed with their indicators approaching the physiological norm. In case of Shigellosis in children with CMV, the content of IL-1β and IL-4 was still significantly high. Violation of the normalization of the cytokine profile of patients with Shigellosis on the background of CMV infection may be one of the leading factors in the torpid clinical recovery, the formation of an unfavorable course of the disease. In our opinion, these features of the cytokine response of patients must be considered during the period of rehabilitation and follow-up.