Jove
Visualize
Contact Us

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NEUTROPHIL TRAPS AS AN IMMUNE RESPONSE MECANISM IN PETIENTS WITH EROSIVE DISEASES OF THE UPPER GASTROINTESTINAL TRACT.

Georgian medical news·2023
Same author

PREOPERATIVE PREPARATION OF DONOR ZONES OF PERFORANT FLAPS BY THE METHOD OF TRAINING PERFORANT VESSELS WITH NEGATIVE PRESSURE.

Georgian medical news·2022
Same author

RESEARCH OF THE TEACHING EFFICIENCY THE SECTION "THERMAL TRAUMA" USING INTERACTIVE TECHNOLOGIES.

Georgian medical news·2022
Same author

QUANTITATIVE HISTOLOGICAL ASSESSMENT OF SKELETAL MUSCLE HYPOTROPHY AFTER NEUROTOMY AND SCIATIC NERVE REPAIR IN RATS.

Georgian medical news·2021
Same author

PERIPHERAL NERVE LESIONS AFTER A MECHANICALLY INDUCED LIMB ISCHEMIA.

Georgian medical news·2021
Same author

EPINEURIAL SUTURES, POLYETHYLENE GLYCOL HYDROGEL AND FIBRIN GLUE IN THE SCIATIC NERVE REPAIR IN RATS: FUNCTIONAL AND MORPHOLOGICAL ASSESSMENTS IN EXPERIMENT.

Georgian medical news·2021
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 2, 2026

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
20:14

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

16.7K

SCIATIC NERVE REGENERATION AFTER AUTOGRAFTING AND APPLICATION OF THE BONE MARROW ASPIRATE CONCENTRATION.

I Gaiovych1, S Savosko2, I Labunets3

  • 11SI "ITONAMSU" Clinic for Microsurgery and Reconstructive-Recovery Surgery the Upper Limb, SI "Institute of Traumatology and Orthopedics of the NAMS.

Georgian Medical News
|December 6, 2019
PubMed
Summary

Autologous bone marrow aspirate concentrate significantly enhanced sciatic nerve regeneration in rabbits. This treatment also delayed muscle atrophy and reduced oxidative stress, supporting nerve repair.

More Related Videos

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.8K
Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

11.4K

Related Experiment Videos

Last Updated: Jan 2, 2026

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
20:14

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

16.7K
Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.8K
Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

11.4K

Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Biochemistry

Background:

  • Sciatic nerve injury leads to regeneration challenges and subsequent muscle atrophy.
  • Autologous bone marrow aspirate concentrate (BMAC) contains regenerative cells and growth factors.
  • Oxidative stress plays a role in nerve injury and muscle degeneration.

Purpose of the Study:

  • To investigate the efficacy of autologous bone marrow aspirate concentrate (BMAC) in promoting sciatic nerve regeneration.
  • To evaluate the impact of BMAC on preventing or delaying muscle atrophy following nerve injury.
  • To assess the biochemical changes, including oxidative stress markers and antioxidant enzyme activity, in the affected muscle.

Main Methods:

  • A rabbit model of sciatic nerve autografting was used.
  • BMAC was prepared from autologous bone marrow and applied around the nerve graft.
  • Nerve regeneration, muscle morphology, oxidative modification products, and antioxidant enzyme activity were assessed at 30 and 90 days.

Main Results:

  • BMAC significantly increased sciatic nerve regeneration percentage within the graft and distal stump at both 30 and 90 days.
  • BMAC application delayed muscle atrophy, preserving a higher percentage of muscle fibers compared to controls.
  • BMAC reduced lipid and protein peroxidation products and enhanced antioxidant enzyme activity (glutathione peroxidase, glutathione reductase).

Conclusions:

  • Autologous bone marrow aspirate concentrate is a promising therapeutic agent for enhancing sciatic nerve regeneration.
  • BMAC mitigates muscle atrophy associated with nerve injury, likely through its anti-oxidative and regenerative properties.
  • The study highlights the supportive role of BMAC cells in nerve repair and muscle preservation.