Related Experiment Video
Updated: Jan 2, 2026
Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
Published on: September 1, 2010
Sonic Hedgehog-Activated Large Cell/Anaplastic Medulloblastoma with Myogenic Differentiation
Shilpa Rao1, Alok Mohan Uppar1, Vani Santosh1
1Departments of Neuropathology and Neurosurgery, National Institute of Mental Health and Neurosciences, Bangladore, India.
Background:
Medulloblastoma (MB) with myogenic differentiation is a rare histologic variant.
Case Description:
We report a case of a 7-year-old female child who presented with a left cerebellar mass. Histopathologic examination showed a cellular neoplasm comprising undifferentiated cells along with foci of bizarre giant cells. Immunohistochemistry revealed that the tumor corresponded to the MB, sonic hedgehog-activated subgroup.
Conclusions:
The case is being reported to document this rare variant of MB that had myogenic differentiation. Molecular characterization of this variant has been analyzed in few cases so far.
