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Updated: Jan 2, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Donor-specific antibodies in liver transplantation
Julien Vionnet1, Christine Sempoux2, Manuel Pascual3
1Institute of Liver Studies, King's College Hospital, London, United Kingdom; Transplantation Centre, University Hospital of Lausanne, Lausanne, Switzerland; Service of Gastroenterology and Hepatology, University Hospital of Lausanne, Lausanne, Switzerland.
Abstract:
Despite unique immunoregulatory properties pointing toward tolerance, the liver allograft can be negatively impacted by humoral alloreactivity, with immediate as well as long-term harmful consequences. With regard to the unmet need of long-term outcomes improvement after liver transplantation, donor-specific antibodies have recently been the matter of intense study in this context. We review here recent advances regarding the understanding of the impact of preformed as well as de novo anti-human leukocyte antigen donor-specific antibodies in liver transplantation and discuss potential strategies to overcome this problem.
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