Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct Cytosolic Delivery of Amphiphilic Framework Nucleic Acids for RNA Interference.

Angewandte Chemie (International ed. in English)·2026
Same author

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Innate Immunity of Framework Nucleic Acids.

Accounts of chemical research·2026
Same author

A multiple-encrypted DNA device for secure communication.

Science advances·2026
Same author

A Point-of-Care System for the Quantification of Small-Molecule Drugs in Blood.

ACS sensors·2026
Same author

Programming Dimensional Transitions in DNA Brick Crystals via Interfacial Connectivity.

Angewandte Chemie (International ed. in English)·2026

Related Experiment Video

Updated: Jan 2, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.0K

Programming DNA origami patterning with non-canonical DNA-based metallization reactions.

Sisi Jia1,2, Jianbang Wang2, Mo Xie2

  • 1School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.

Nature Communications
|December 8, 2019
PubMed
Summary

This study introduces a novel DNA origami method for precise metal patterning at the nanoscale. This bio-inspired technique enables highly accurate metal deposition on DNA structures for advanced applications.

More Related Videos

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.7K
Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
09:17

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

9.1K

Related Experiment Videos

Last Updated: Jan 2, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.0K
Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.7K
Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
09:17

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

9.1K

Area of Science:

  • Nanotechnology
  • Bioengineering
  • Materials Science

Background:

  • DNA hybridization is widely used in bioengineering, but DNA's structural potential for non-canonical reactions remains underexplored.
  • Existing methods for nanoscale patterning often lack precision or versatility.

Purpose of the Study:

  • To develop a DNA origami-enabled method for highly localized metallization reactions.
  • To achieve intrinsic metallization patterning with 10-nm resolution on DNA substrates.
  • To explore the fabrication of nanoscale printed circuit board (nano-PCB) mimics.

Main Methods:

  • Utilized two-dimensional DNA origami scaffolds with prescribed protruding clustered DNA (pcDNA) sites.
  • Investigated the coordination of low-valence metal ions (Cu²⁺ and Ag⁺) with DNA bases within pcDNA.
  • Performed theoretical and experimental studies to understand site-specific metallization and condensation.

Main Results:

  • Achieved metallization patterning with 10-nm resolution, selectively occurring on prescribed pcDNA sites.
  • Demonstrated the generic applicability of the strategy for free-style metal painting of various shapes on DNA substrates with near-unity efficiency.
  • Successfully fabricated single- and double-layer nano-PCB mimics using the developed technique.

Conclusions:

  • The DNA origami-enabled metallization reaction offers a highly precise and versatile platform for nanoscale patterning.
  • This bio-inspired fabrication approach holds significant potential for advancing nanoelectronic and nanophotonic applications.
  • The method provides a new route for creating complex, custom metal patterns on all-DNA substrates.