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Vaccine-Associated Anaphylaxis.

Michael M McNeil1

  • 1Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Zoonotic and Emerging Infectious Diseases, Centers for Disease Control and Prevention, Mailstop V18-4, CDC, 1600 Clifton Rd, Atlanta, GA, 30333, USA.

Current Treatment Options in Allergy
|December 10, 2019
PubMed
Summary
This summary is machine-generated.

Anaphylaxis following vaccination is rare. Recent studies confirm its rarity, with incidence rates low for all vaccines and influenza vaccines, but preparedness for anaphylaxis management is crucial.

Keywords:
AnaphylaxisInfluenza vaccinationSurveillanceVaccine safety

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Area of Science:

  • Vaccinology
  • Immunology
  • Public Health

Background:

  • Anaphylaxis is a rare but serious hypersensitivity reaction post-vaccination.
  • Understanding anaphylaxis risk is crucial due to widespread annual vaccination, especially for influenza vaccines.

Purpose of the Study:

  • To confirm the rarity of post-vaccination anaphylaxis.
  • To assess the incidence of anaphylaxis following various vaccines, with a focus on influenza vaccines.

Main Methods:

  • Analysis of 25-year data from the Vaccine Adverse Event Reporting System (VAERS).
  • Evaluation of a Vaccine Safety Datalink (VSD) study on anaphylaxis incidence.

Main Results:

  • Post-vaccination anaphylaxis is confirmed as rare in recent CDC safety studies.
  • In VAERS data, anaphylaxis reports were most frequent after childhood vaccines in children and influenza vaccines in adults.
  • The estimated incidence of anaphylaxis was 1.3 per million doses for all vaccines and 1.6 per million doses for trivalent influenza vaccine (IIV3).

Conclusions:

  • Despite its rarity, anaphylaxis has a rapid onset and can be lethal.
  • All vaccination providers must have established procedures for managing anaphylaxis.