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Related Concept Videos

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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Atomic Absorption Spectroscopy: Interference01:25

Atomic Absorption Spectroscopy: Interference

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Interference leads to systematic error in atomic absorption (AA) measurements by enhancing or diminishing the analytical signal or the background. These interferences can be grouped into three main categories: spectral interference, chemical interference, and physical interference.
Spectral interference occurs when signals from other elements or molecules overlap with the analyte signal, falsely elevating or masking the analyte's absorbance. This interference can be corrected using Zeeman,...
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Interdisciplinary Care: The Health Care Team-II01:18

Interdisciplinary Care: The Health Care Team-II

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An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care. Here are a few more healthcare professionals.
Physical Therapist
A physical therapist (PT) aims to restore function or prevent additional impairment in a patient following an injury or disease. Massage, heat, cold, water, sonar waves, exercises, and electrical stimulation are some treatments used by PTs to treat...
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Confounding in Epidemiological Studies01:27

Confounding in Epidemiological Studies

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Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
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Atomic Emission Spectroscopy: Interference01:30

Atomic Emission Spectroscopy: Interference

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In atomic emission spectroscopy (AES), high-temperature atomizers excite a broad range of elements and molecules that generate complex emissions from sources such as oxides, hydroxides, and flame combustion products in the flame or plasma. Several strategies can be employed to minimize spectral interferences caused by overlapping emission lines or bands. These include increasing instrument resolution, choosing alternative emission lines, optimally placing the detector in low-background regions,...
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Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

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In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
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Understanding Clinical Laboratory Interference.

Caren McHenry Martin

    The Senior Care Pharmacist
    |December 11, 2019
    PubMed
    Summary

    Laboratory interference can cause inaccurate test results, leading to misdiagnosis and incorrect medication management, especially in elderly patients. Understanding these common interference sources is crucial for healthcare providers to ensure patient safety.

    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Patient Safety

    Background:

    • Laboratory tests are vital for disease diagnosis and medication management.
    • Laboratory interference, caused by sample properties, can lead to diagnostic and therapeutic errors.
    • Certain interference types disproportionately affect elderly individuals.

    Purpose of the Study:

    • To highlight common sources of laboratory interference.
    • To inform healthcare practitioners about potential inaccuracies in laboratory results.
    • To improve the assessment of laboratory data validity, particularly for the elderly.

    Main Methods:

    • Review of common endogenous and exogenous sources of laboratory interference.
    • Analysis of interference impact on diagnostic and therapeutic decisions.

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  • Focus on interference prevalent in elderly populations.

    • Main Results:

    • Laboratory interference can significantly compromise the accuracy of diagnostic and therapeutic monitoring.
    • Awareness of interference sources is critical for correct interpretation of laboratory values.
    • Elderly patients may be more susceptible to specific types of laboratory interference.

    Conclusions:

    • Healthcare professionals must recognize and address laboratory interference to prevent patient harm.
    • Accurate interpretation of laboratory results requires understanding potential confounding factors.
    • Further research into mitigating interference in vulnerable populations is warranted.