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Updated: Jan 2, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
Published on: February 10, 2014
Water Soluble G-protein Coupled Receptor Enabled Biosensors
Renyu Liu1, A T Charlie Johnson2, Jeffery G Saven3
1Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, USA.
Abstract:
This article will briefly overview our efforts in the engineering of water soluble variants of a G-protein coupled receptor (GPCR) and its novel applications to develop biosensors using such water soluble variants of GPCR. While the technologies using water soluble GPCR are still under development, they offer new tools and strategies to study the function of GPCR, explore potential new compounds for potential clinical usage, and monitor endogenous peptides in various physiological and pathological conditions.
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