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Updated: Jan 2, 2026
Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
Published on: February 9, 2024
Accelerated DNAzyme-based fluorescent nanoprobe for highly sensitive microRNA detection in live cells
Yanan Wu1, Hong-Min Meng, Juan Chen
1Institute of Chemical Biology and Clinical Application at the First Affiliated Hospital, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China. zhaohui.li@zzu.edu.cn qulingbo@zzu.edu.cn hmmeg2017@zzu.edu.cn.
Abstract:
By assembling DNAzyme on DNA nanowires through DNA hybridization, we have developed a novel accelerated DNAzyme-based fluorescent nanoprobe for fast, sensitive and selective detection of miRNA. Moreover, the strategy was successfully applied for in situ imaging of miRNA-21 in different cell lines.
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