Related Experiment Video
Updated: Jan 2, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Comparison of prescribing patterns before and after implementation of evidence-based opioid prescribing guidelines
Matthew Ziegelmann1, Jason Joseph1, Amy Glasgow2
1Department of Urology, Mayo Clinic, Rochester, MN, USA.
Background:
We developed evidence-based guidelines for postoperative opioid prescribing after urologic surgery and assessed changes in prescribing after implementation.
Methods:
Prescribing data for adults who underwent 21 urologic procedures were used to derive a four-tiered guideline for postoperative opioid prescribing. This was implemented on January 1, 2018, and prescribing patterns including quantity of opioids prescribed (oral morphine equivalents; OME) and refill rates were compared between patients undergoing surgery prior to (January-April, 2017; n equals 1732) and after (January-April, 2018; n equals1376) implementation.
Results:
The median OME (IQR) prescribed was significantly lower for 2018 compared with 2017 [100 (0; 175) versus 150 (60; 225); p < .0001]. The median prescribed OME decreased in 14/21 procedures (67%). The refill rates did not significantly change. Guideline adherence rates after implementation, based on individual procedures, ranged from 33 to 95%.
Conclusions:
Fewer opioids were prescribed after implementing a prescribing guideline. Additional study is required to assess patient opioid utilization.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Peripheral Artery Disease V: Postoperative Nursing Management
Opioid Analgesics: Morphine and Other Natural Cogeners
Analgesia and Pain Management
Cardiomyopathy VII: Pre and Post Operative Nursing Management

