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Scleral Lens Sensor for Ocular Electrolyte Analysis.

Ali K Yetisen1, Nan Jiang2, Carmen M Castaneda Gonzalez1

  • 1Institute for Measurement Systems and Sensor Technology, Technical University of Munich, Munich, D-80290, Germany.

Advanced Materials (Deerfield Beach, Fla.)
|December 14, 2019
PubMed
Summary
This summary is machine-generated.

A novel fluorescent scleral lens sensor enables quantitative tear analysis for early ocular disease diagnosis. This point-of-care system accurately measures key ions and pH, aiding in dry eye assessment.

Keywords:
biosensorsdiagnosticsophthalmologyscleral lensessmartphones

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Area of Science:

  • Ophthalmology and Biomedical Engineering
  • Analytical Chemistry
  • Sensing Technologies

Background:

  • Early diagnosis of ocular diseases is crucial for effective treatment.
  • Current diagnostic methods may lack point-of-care convenience and comprehensive analyte analysis.
  • Tear fluid contains vital biomarkers for eye health assessment.

Purpose of the Study:

  • To develop a multiplexed fluorescent scleral lens sensor for quantitative tear analyte analysis.
  • To enable point-of-care measurement of pH, Na+, K+, Ca2+, Mg2+, and Zn2+ ions.
  • To create a handheld system for diagnosing ocular conditions like dry eye.

Main Methods:

  • Fabrication of a scleral lens with multiplexed fluorescent sensors for specific ions and pH.
  • Development of a handheld ophthalmic readout device with LEDs and bandpass filters.
  • Integration of a smartphone application for quantitative data acquisition and analysis.

Main Results:

  • Demonstrated quantitative measurement of physiological tear levels for pH, Na+, K+, Ca2+, Mg2+, and Zn2+ ions.
  • Achieved specific sensitivities and detection ranges for each ion and pH probe.
  • Validated the system's capability for assessing dry eye severity and subtypes.

Conclusions:

  • The developed fluorescent scleral lens sensor system offers a promising point-of-care solution for ocular diagnostics.
  • Multiplexed sensing in a scleral lens allows for comprehensive tear analysis.
  • This technology can significantly aid in the early detection and management of eye diseases, particularly dry eye.