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THE INCIDENCE OF MULTIPLE MYELOMA IN THE DNIPROPETROVSK REGION
I O Selina1, O O Yarchuk2, P Yu Kaplan2
1KZ «Dnipropetrovsk City Multidisciplinary Clinical Hospital No 4» DOR»Department of Occupational Pathology and Clinical Immunology, DZ «Dnipropetrovsk State Medical Academy, Ministry of Health of Ukraine.
Objective:
To conduct a comparative analysis of the incidence of MM in the population of the Dnipropetrovsk region, taking into account the possible impact of various adverse environmental factors (air, water and soil con- tamination).
Materials And Methods:
Epidemiological indicators of multiple myeloma (MM) morbidity in the 12-year observation period from 2006 to 2017 are analyzed in polluted and conventionally clean areas of the Dnipropetrovsk region.
Results:
In assessing the dynamics of morbidity in MM for years 2006-2017 there was an increase in the incidence in 2011, 2015 and quite stable indicators for 2006-2010. The analysis of morbidity in the industrial cities of the region showed consistently high rates for the entire period of observation. A marked increase in the incidence rate in the Zhovti Vody (2007, 2012, 2016), Nikopol (2016), Novomoskovsk (2016), Marganets (2008, 2009 and 2017), Pokrov (2016, 2017) from 4.35 to 6.25 was noted. This may indicate a fluctuation in the incidence of MM in sepa- rate large cities of Dnipropetrovsk. The analysis of the dynamics of morbidity in the most polluted cities showed a clear increase in the number of cases in the MM in Zhovti Vody, which is characterized by radiation pollution. According to the average annual morbidity rate among cities of Dnipropetrovsk region, Pokrov takes the first place, the second - Zhovti Vody.
Conclusions:
The obtained data testify to the fluctuation in the incidence of MM in the Dnipropetrovsk region during the period 2006-2017 and the negative environmental factors clearly affect the growth of morbidity in large industrialized cities contaminated with radioactive and chemical substances.
Insights
Multiple myeloma (MM) incidence fluctuated in Dnipropetrovsk from 2006-2017. Environmental factors, particularly radiation and chemical contamination in industrial cities, appear to drive increased MM morbidity rates.
Area of Science:
- Epidemiology
- Environmental Health
- Oncology
Background:
- Multiple myeloma (MM) is a cancer of plasma cells.
- Environmental factors are increasingly recognized for their potential role in cancer etiology.
- The Dnipropetrovsk region has significant industrial activity and associated environmental concerns.
Purpose of the Study:
- To compare the incidence of multiple myeloma (MM) in the Dnipropetrovsk region.
- To investigate the potential impact of adverse environmental factors, including air, water, and soil contamination, on MM rates.
- To analyze MM morbidity trends between 2006 and 2017 in relation to pollution levels.
Main Methods:
- Epidemiological analysis of multiple myeloma (MM) morbidity data from 2006 to 2017.
- Comparison of MM incidence rates in polluted versus conventionally clean areas within the Dnipropetrovsk region.
- Assessment of MM morbidity dynamics in specific industrial cities known for environmental contamination.
Main Results:
- MM incidence showed fluctuations between 2006-2017, with peaks in 2011 and 2015.
- Industrial cities consistently exhibited high MM morbidity rates throughout the observation period.
- Significant increases in MM incidence were noted in cities like Zhovti Vody (radiation-polluted), Pokrov, and Nikopol, with Pokrov and Zhovti Vody showing the highest average annual rates.
Conclusions:
- Multiple myeloma (MM) incidence in the Dnipropetrovsk region varied between 2006-2017.
- Adverse environmental factors, including radioactive and chemical contamination, are strongly implicated in the rise of MM morbidity in industrialized urban areas.
- Further research is warranted to elucidate specific causal links between environmental pollutants and MM development.
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