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Advances and considerations in AD tau-targeted immunotherapy
Alice Bittar1, Nemil Bhatt2, Rakez Kayed1
1Department of Neurology, The Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States of America.
Neurobiology of Disease
|December 17, 2019
Summary
This review explores tau-targeted immunotherapy for Alzheimer's disease (AD), focusing on pathological tau species and combination therapies. Tau immunotherapy offers a new direction for AD treatment beyond amyloid beta strategies.
Area of Science:
- Neuroscience
- Immunology
- Pharmacology
Background:
- Alzheimer's disease (AD) is multifactorial, complicating therapeutic target identification.
- Emerging evidence highlights tau protein's critical role in AD etiology and propagation.
- Previous amyloid beta (Aß)-targeted immunotherapies have shown limited success.
Purpose of the Study:
- To review recent advancements in tau-targeted immunotherapy for Alzheimer's disease.
- To discuss AD-relevant tau species and their pathological significance.
- To explore promising biomarkers and combination therapy strategies for AD.
Main Methods:
- Comprehensive literature review of experimental and clinical studies on tau immunotherapy.
- Analysis of research on pathological tau protein forms and their role in AD.
- Evaluation of current and emerging biomarkers for AD diagnosis and progression.
Main Results:
- Tau-targeted immunotherapy is a promising therapeutic avenue for AD.
- Understanding diverse pathological tau species is crucial for effective treatment.
- Combination therapies are likely necessary, as immunotherapy alone may be insufficient.
Conclusions:
- Tau immunotherapy represents a significant shift in AD therapeutic strategies.
- Further research into tau species, biomarkers, and combination therapies is warranted.
- A multi-pronged approach is essential to effectively combat Alzheimer's disease progression.
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