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Conformational exchange in the potassium channel blocker ShK

Naoto Iwakawa1,2, Nicola J Baxter2, Dorothy C C Wai3

  • 1Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto-Daigaku Katsura, Nishikyo-Ku, Kyoto, 615-8510, Japan.

Scientific Reports
|December 19, 2019
PubMed
Summary

High hydrostatic pressure reveals the active structure of ShK, a sea anemone peptide blocking potassium channels. This conformational insight aids in developing treatments for autoimmune diseases like psoriasis.

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