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Updated: Jan 1, 2026
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
The CD14 gene -159C/T polymorphism and the risk of ischemic stroke: a meta-analysis
Meihua Xu1, Linghua Wang2, Lihua Sun1
1Department of Neurology, Hangzhou Red Cross Hospital, Hangzhou, China.
Background:
To investigate the association between the CD14 -159C/T polymorphism and ischemic stroke (IS).
Methods:
Relevant literature was searched by retrieving EMBASE, Web of Science, Chinese National Knowledge Infrastructure, and PubMed databases. R version 3.33 software was applied to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).
Results:
Seven qualified studies with a total of 2058 IS patients and 2123 controls were included. There was no significant association between the CD14 -159C/T polymorphism and IS risk in the total population (TT vs CC: OR = 0.84, 95% CI = 0.58-1.20; CT vs CC: OR = 0.96, 95% CI = 0.82-1.12; dominant model: OR = 1.02, 95% CI = 0.80-1.30; recessive model: OR = 0.82, 95% CI = 0.57-1.19). Similarly, subgroup analysis according to ethnicity and Hardy-Weinberg equilibrium also found no significant interrelation.
Conclusion:
Our findings suggest that the CD14 -159C/T polymorphism does not contribute to the risk of IS. Well-designed studies with more subjects are required to further validate these results.
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