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Hyaluronic acid in otology: Its uses, advantages and drawbacks - A review
Christophe Abi Zeid Daou1, Marc Bassim1
1American University of Beirut Medical Center, P.O. Box 11-0236, Department of Otolaryngology and Head and Neck Surgery, Riad El-Solh, Beirut 1107 2020, Lebanon.
Objectives:
Review of the literature for studies involving the use of hyaluronic acid (HA) in otology.
Methods:
Pubmed and OvidMedline were searched using a combination of the following words in different variations: hyaluronic acid, hyaluronate, otolaryngology, otology, ear, tympanic membrane, perforation, tympanostomy, tympanoplasty, myringoplasty, packing, middle ear, cochlea, gene delivery, gene therapy, cochlear implant, hearing loss, meniere, vertigo, otitis and cholesteatoma.
Results:
The papers relevant for this review were triaged based on abstracts and titles and were then categorized based on topic/disease entity/procedure. The papers were read and summarized in order to use their findings in this review.
Conclusions:
HA is being recently used as adjuvant therapy for multiple inflammatory conditions and in tissue repair. These immunomodulatory properties and biocompatibility have interested researchers specially in the field of otology for repair, gene delivery, immunomodulation etc. Recent data in the field show optimistic results for the use of HA in several conditions especially tympanic membrane perforations and gene delivery. It also establishes the role of HA as ancillary treatment in many other otologic pathologies. This review presents the most recent findings on the use of HA in otology. The results could be used to guide clinical practice and incite further research based on the presented results of the literature.
