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The influence of dopaminergic polymorphisms on selective stopping
I Rincón-Pérez1, V Echeverry-Alzate2, A J Sánchez-Carmona1
1Instituto Pluridisciplinar, Universidad Complutense de Madrid, Madrid, Spain.
Behavioural Brain Research
|December 22, 2019
Summary
Genetic variations in COMT and DRD2 influence strategy choice, not speed, in selective stopping tasks. This research sheds light on the genetic underpinnings of complex inhibitory control strategies.
Area of Science:
- Neuroscience
- Behavioral Genetics
Background:
- Inhibitory control is crucial for cognitive function.
- Selective stopping, a complex form of inhibition, is not well understood genetically.
- Dopaminergic system plays a role in executive functions.
Purpose of the Study:
- To investigate the influence of COMT and DRD2 polymorphisms on stimulus-selective stopping.
- To examine how these genetic variations affect selective and non-selective stopping strategies.
Main Methods:
- Utilized the stimulus-selective stop-signal task in a sample of 529 adults.
- Analyzed the impact of specific dopaminergic polymorphisms (COMT, DRD2) on stopping behavior.
- Assessed both the latency of the stop process and the choice of stopping strategy.
Main Results:
- No significant effect of COMT or DRD2 polymorphisms on stop-signal reaction time (SSRT) was observed.
- An interaction between COMT and DRD2 polymorphisms significantly influenced the choice of stopping strategy.
- This suggests a genetic modulation of strategy adoption in selective stopping.
Conclusions:
- Dopaminergic gene polymorphisms may influence how individuals approach selective stopping tasks.
- The interaction between COMT and DRD2 is a key factor in strategy selection for inhibitory control.
- This study provides novel insights into the genetic basis of complex cognitive control mechanisms.
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