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Could Management of Blood Pressure Prevent Dementia in the elderly?

Masaki Mogi1

  • 1Department of Pharmacology, Ehime University, Graduate School of Medicine, Matsuyama, Japan.

Clinical Hypertension
|December 24, 2019
PubMed

Insights

High blood pressure in mid-life is a risk factor for dementia. While treating hypertension in the elderly may not prevent dementia, regulating the renin-angiotensin system offers therapeutic potential.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Geriatrics

Background:

  • Hypertension is a significant risk factor for vascular aging, stroke, and vascular dementia (VD).
  • Mixed dementia (Alzheimer's disease and VD) prevalence increases in the elderly.
  • Vascular disorders are implicated in the onset and progression of Alzheimer's disease (AD).

Purpose of the Study:

  • To discuss the role of elevated blood pressure in dementia.
  • To explore the therapeutic potential of antihypertensive treatments for dementia.

Main Methods:

  • Reviewing the relationship between mid-life hypertension and dementia incidence.
  • Investigating the involvement of the renin-angiotensin system (RAS) in hypertension and dementia.
  • Considering the impact of small vessel structural changes in lifestyle-related diseases on elderly dementia.

Main Results:

  • Mid-life hypertension is linked to dementia incidence.
  • Antihypertensive treatment in the elderly has not consistently prevented dementia onset or progression.
  • The renin-angiotensin system is implicated in hypertension, lifestyle diseases, and potentially dementia pathology.

Conclusions:

  • Elevated blood pressure plays a crucial role in dementia.
  • Regulation of the renin-angiotensin system presents a potential therapeutic strategy for dementia prevention.
  • Small vessel changes associated with lifestyle-related diseases may contribute to dementia in older adults.
Abstract

Keywords:
Blood brain barrierHypertensionMixed dementiaRenin-angiotensin systemVascular degeneration

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