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Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus
Shahin Safian1, Farzaneh Esna-Ashari2, Shiva Borzouei3
1Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Aims:
Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus.
Background:
This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM).
Methods:
A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24-28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22.
Results:
There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008).
Conclusion:
Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely.
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