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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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DNA Microarrays02:34

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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Related Experiment Video

Updated: Jan 1, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

411.1K

[3D Genomics].

S V Razin1,2,3, S V Ulianov1,2, A A Gavrilov1

  • 1Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia.

Molekuliarnaia Biologiia
|December 27, 2019
PubMed
Summary

New research reveals the genome

Area of Science:

  • Genomics and Molecular Biology
  • Structural Biology
  • Epigenetics

Background:

  • The 3D genome organization is crucial for gene regulation and function.
  • Emerging research methods have unveiled the genome's structural-functional units.
  • Spatial genome organization influences enhancer activity and gene expression.

Purpose of the Study:

  • To review key discoveries in 3D genomics.
  • To discuss the role of genome spatial organization in gene regulation.
  • To explore the implications of 3D genome structure in disease and future research directions.

Main Methods:

  • Review of recent advancements in 3D genomics research.
  • Analysis of studies investigating genome spatial organization.
  • Synthesis of findings on the link between 3D genome structure and gene function.
Keywords:
chromatinchromosome conformation capturestructural-functional genome domainstopologically associated domains

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Related Experiment Videos

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Main Results:

  • The genome is organized into structural-functional units that limit enhancer action.
  • Spatial reconfiguration of genomic regions can activate or repress genes.
  • Disruptions in 3D genome organization are linked to diseases like cancer.

Conclusions:

  • 3D genomics is a rapidly advancing field with significant implications for understanding genome function.
  • Altered 3D genome structure is a key factor in various pathologies.
  • Further research in 3D genomics promises new insights into gene regulation and disease mechanisms.