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[Invasive Streptococcus pyogenes infections (2011-2018): EMM-type and clinical presentation]

María José González-Abad1, Mercedes Alonso Sanz1

  • 1Sección de Microbiología, Servicio de Análisis Clínicos, Hospital Infantil Universitario Niño Jesús, Madrid, España.

Anales De Pediatria
|December 28, 2019
PubMed
Abstract

Insights

Invasive Streptococcus pyogenes infections increased from 2011-2018, with M1 and M3 types being most common. These M types were linked to pneumonia and deep soft tissue infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Streptococcus pyogenes (S. pyogenes) causes significant human infections, ranging from mild to severe invasive diseases.
  • The M protein (emm type) is a key virulence factor in S. pyogenes.
  • Recent years have seen a rise in invasive S. pyogenes disease, particularly linked to M1 and M3 types.

Purpose of the Study:

  • To confirm the resurgence of invasive S. pyogenes disease between 2011 and 2018.
  • To investigate the association between specific S. pyogenes M types and clinical disease presentation.

Main Methods:

  • Bacterial isolates were identified using standard microbiological techniques and confirmed with specific antisera.
  • Antibiotic susceptibility testing was performed using microdilution methods.
  • Molecular analysis included emm gene sequencing and superantigen profiling.

Main Results:

  • Twenty-nine invasive S. pyogenes isolates were collected between 2011 and 2018.
  • The incidence of invasive isolates increased annually from 2014 onwards.
  • M1 (11 isolates) and M3 (3 isolates) were the predominant types, strongly correlated with pneumonia and deep soft tissue infections.

Conclusions:

  • The study confirms an increased incidence of invasive S. pyogenes disease during the 2011-2018 period.
  • M1 and M3 S. pyogenes types were most frequently isolated.
  • These prevalent M types were significantly associated with severe clinical presentations like pneumonia and deep soft tissue infections.
Keywords:
Emm-typeInfecciones invasorasInvasive infectionsSerotipo MStreptococcus pyogenes

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