[Invasive Streptococcus pyogenes infections (2011-2018): EMM-type and clinical presentation].
María José González-Abad1, Mercedes Alonso Sanz1
1Sección de Microbiología, Servicio de Análisis Clínicos, Hospital Infantil Universitario Niño Jesús, Madrid, España.
Anales De Pediatria
|December 28, 2019
Summary
Invasive Streptococcus pyogenes infections increased from 2011-2018, with M1 and M3 types being most common. These M types were linked to pneumonia and deep soft tissue infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Epidemiology
Background:
- Streptococcus pyogenes (S. pyogenes) causes significant human infections, ranging from mild to severe invasive diseases.
- The M protein (emm type) is a key virulence factor in S. pyogenes.
- Recent years have seen a rise in invasive S. pyogenes disease, particularly linked to M1 and M3 types.
Purpose of the Study:
- To confirm the resurgence of invasive S. pyogenes disease between 2011 and 2018.
- To investigate the association between specific S. pyogenes M types and clinical disease presentation.
Main Methods:
- Bacterial isolates were identified using standard microbiological techniques and confirmed with specific antisera.
- Antibiotic susceptibility testing was performed using microdilution methods.
- Molecular analysis included emm gene sequencing and superantigen profiling.
Main Results:
- Twenty-nine invasive S. pyogenes isolates were collected between 2011 and 2018.
- The incidence of invasive isolates increased annually from 2014 onwards.
- M1 (11 isolates) and M3 (3 isolates) were the predominant types, strongly correlated with pneumonia and deep soft tissue infections.
Conclusions:
- The study confirms an increased incidence of invasive S. pyogenes disease during the 2011-2018 period.
- M1 and M3 S. pyogenes types were most frequently isolated.
- These prevalent M types were significantly associated with severe clinical presentations like pneumonia and deep soft tissue infections.
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