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Correlation between Gout and Coronary Heart Disease in Taiwan: A Nationwide Population-Based Cohort Study

Kuang-Hua Huang1, Chih-Jaan Tai1,2, Ya-Fang Tsai3

  • 1Department of Health Services Administration, China Medical University.

Acta Cardiologica Sinica
|December 28, 2019
PubMed

Insights

Gout patients face a higher risk of coronary heart disease (CHD). This risk is influenced by age, hypertension, hyperlipidemia, and diabetes mellitus, underscoring the link between inflammatory arthritis and cardiovascular health.

Area of Science:

  • Rheumatology and Cardiology
  • Epidemiology
  • Public Health

Background:

  • Gout is a prevalent inflammatory arthritis in adult males.
  • Gout diagnosis is associated with an increased risk of coronary heart disease (CHD).
  • Understanding this association is crucial for patient management and cardiovascular risk stratification.

Purpose of the Study:

  • To investigate the correlation between gout and the incidence of coronary heart disease (CHD).
  • To identify other risk factors associated with CHD in patients with gout.

Main Methods:

  • A retrospective cohort study utilizing the Longitudinal Health Insurance Database of Taiwan.
  • Inclusion of 46,140 patients diagnosed with new-onset gout between 2003 and 2010.
  • Propensity score matching and Cox proportional hazard modeling to analyze CHD risk.

Main Results:

  • Patients with gout exhibited a significantly higher risk of CHD (adjusted HR = 1.34, 95% CI: 1.23-1.45).
  • CHD risk escalated with increasing age.
  • Hypertension (adjusted HR = 1.53), diabetes mellitus (adjusted HR = 1.24), and hyperlipidemia (adjusted HR = 1.18) were significant risk factors.

Conclusions:

  • A significant correlation exists between gout and coronary heart disease (CHD).
  • Hypertension, hyperlipidemia, and diabetes mellitus are key influencing factors for CHD in gout patients.
  • Age and gender also demonstrate associations with CHD risk.
Abstract

Keywords:
Coronary heart diseaseGoutHyperuricemiaRisk factor

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