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Histopathological kidney changes and myoglobinuria in neotropical non-human primates attacked by dogs, Brazil
Natália Coelho Couto de Azevedo Fernandes1,2, Paloma Martins do Nascimento1, Angélica M Sánchez-Sarmiento2
1Centro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Background:
Non-human primates (NHPs) are susceptible to dogs' attacks, events that may cause muscle damage along with stress, and could be in some extent compatible with capture myopathy, a syndrome that results in myoglobinuria and renal damage.
Methods:
We aimed to evaluate by histopathology pre-existing lesions and subsequent sequelae related to dogs' attacks, acute tubular necrosis (ATN) and myoglobinuria, as well as the usefulness of Pearls Stain and IHC to diagnose it. Histopathology was performed in available organs, and sections of kidney submitted to Prussian blue stain and myoglobin immunohistochemistry.
Results:
During January 2014-June 2016, 16/145 (11%) of NHPs received by Adolfo Lutz Institute, Brazil were reported as attacked by dogs. A high frequency of young and debilitated animals was found. Myoglobinuria was observed in more than half animals (9/16; 56.2%), from which (5/9; 55.5%) presented ATN.
Conclusions:
Kidney lesions are plausible findings in NHPs attacked by dogs.
