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Updated: Jan 1, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Decoding the Notch signal
Julia Falo-Sanjuan1, Sarah J Bray1
1Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK.
Abstract:
Notch signalling controls many key cellular processes which differ according to the context where the pathway is deployed due to the transcriptional activation of specific sets of genes. The pathway is unusual in its lack of amplification, also raising the question of how it can efficiently activate transcription with limited amounts of nuclear activity. Here, we focus on mechanisms that enable Notch to produce appropriate transcriptional responses and speculate on models that could explain the current gaps in knowledge.
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