Related Experiment Video
Updated: Dec 31, 2025
07:44
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
3.3K
The correlation between optical coherence tomography retinal shape irregularity and axial length.
Stewart Lake1,2, Murk Bottema2, Keryn Williams1
1Ophthalmology, College of Medicine and Public Health, Flinders University, Adelaide, South Australia.
Plos One
|December 31, 2019
Summary
Optical coherence tomography (OCT) reveals that retinal contour irregularity increases with longer axial length in the eye. This finding highlights a correlation between the eye
Area of Science:
- Ophthalmology
- Medical Imaging
- Biometry
Background:
- Optical coherence tomography (OCT) is crucial for visualizing retinal structures.
- Axial length is a key biometric parameter in ophthalmology, influencing refractive error and ocular health.
- Understanding retinal contour variations is important for diagnosing and managing eye conditions.
Purpose of the Study:
- To characterize the shape of the retinal contour using OCT imaging.
- To investigate the relationship between retinal contour morphology and axial length.
Main Methods:
- Retinal pigment epithelial (RPE) line path analyzed in macular and extra-macular OCT scans from 70 participants.
- Retinal contour shape quantified using best-fit curvature (K) and Fourier analysis.
- Shape irregularity metrics (sumdiff, MaxE, rmse) correlated with axial length.
Main Results:
- Significant correlations found between retinal shape irregularity metrics and axial length.
- Increased irregularity observed with longer axial lengths, particularly in macular and inferior regions.
- Specific Fourier transformation parameters (sumdiff, rmse, MaxE) and curvature range (IQR K) showed strong correlations.
Conclusions:
- Retinal contour in OCT images becomes more irregular as axial length increases.
- The range of retinal curvature, but not the median curvature, is associated with axial length.
- These findings provide quantitative insights into ocular biometry and retinal morphology.
