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Updated: Dec 31, 2025

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
Published on: July 7, 2017
[THE ROLE OF INTERLEUKIN 8 / CXCL8 IN THE IMMUNOPATHOGENESIS AND CARCINOGENESIS OF INFLAMMATORY BOWEL DISEASES
A Doszhan1, R Bektayeva1, N Imanbayeva1
1JSC «Astana Medical University», Department of Internal Medicine #2, Nur-Sultan, Kazakhstan.
Abstract:
The aim of this review was to analyze and synthesize recent data on the role of interleukin 8/CXCL8 in key mechanisms of the inflammatory process and carcinogenesis in patients with inflammatory bowel disease (IBD). Currently, the study of the relationship between the pathogenesis of cancer and chronic inflammation remains an urgent task for many researchers. It has been proven that the strongest correlation between the duration of inflammation and oncogenesis is observed in colorectal cancer (CRC). The discovery of interleukin 8 / CXCL8 as one of the powerful mediators of inflammation has expanded the general understanding of its contribution to the pathogenesis of IBD. This review emphasizes the role of CXCL8 in carcinogenesis in IBD, presents the results of studies on the molecular mechanisms of CXCL8 expression in IBD and CRC, and describes its properties as one of the main angiogenic and pro-inflammatory factors that regulate the cancer cells proliferation. Study of the effects of CXCL8 on signaling pathways activation may serve as a prerequisite for the search for and discovery of new therapeutic approaches, that will reduce the risk of CRC in patients with IBD.
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