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Updated: Dec 31, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Efficient and Practical Transfer Hydrogenation of Ketones Catalyzed by a Simple Bidentate Mn-NHC Complex
Robbert van Putten1, Joeri Benschop1, Vincent J de Munck1
1Inorganic Systems Engineering group, Department of Chemical Engineering Faculty of Applied Sciences Delft University of Technology Van der Maasweg 9 Delft 2629 HZ (The Netherlands.
Abstract:
Catalytic reductions of carbonyl-containing compounds are highly important for the safe, sustainable, and economical production of alcohols. Herein, we report on the efficient transfer hydrogenation of ketones catalyzed by a highly potent Mn(I)-NHC complex. Mn-NHC 1 is practical at metal concentrations as low as 75 ppm, thus approaching loadings more conventionally reserved for noble metal based systems. With these low Mn concentrations, catalyst deactivation is found to be highly temperature dependent and becomes especially prominent at increased reaction temperature. Ultimately, understanding of deactivation pathways could help close the activity/stability-gap with Ru and Ir catalysts towards the practical implementation of sustainable earth-abundant Mn-complexes.
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