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Assessing Drug Release from Manipulated Abuse Deterrent Formulations.

Xin Feng1, Ahmed Zidan1, Nahid S Kamal1

  • 1Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Testing and Research, Division of Product Quality Research, U.S. Food and Drug Administration, Silver Spring, Maryland, 20993, USA.

AAPS Pharmscitech
|January 4, 2020
PubMed
Summary

Developing effective in vitro dissolution methods is crucial for abuse deterrent formulations (ADFs). The United States Pharmacopeia (USP) Apparatus 4 demonstrated superior ability to discriminate particle size effects on drug release compared to other methods.

Keywords:
USP Apparatus 4abuse-deterrent formulationdissolutionmanipulationopioid abusepowder dissolution

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